The Cellgel Method

Having been adopted in over 54 countries globally,
the "Cellgel Method" for treating lower back pain
is now available in Japan

For those who have been told it was impossible to operate,
For those who have had recurrence of pain post-surgery,
A low-risk, outpatient treatment is now an option for you.

back pain image

What is the Cellgel method?

An intervertebral disc-repairing impant gel treatment

The Cellgel method is an advanced treatment for low back pain that has been implemented in more than 54 countries worldwide, predominantly in Europe.
As with other treatments, it does not decrease the disc volume, and since the drug remains in the disc as a gel-like implant after treatment, the disc can be preserved. Recent studies have also shown that the volume of the disc increases after treatment.*1

It is also thought that by repairing the disc and preventing leakage of the Nucleus Pulposus, the disc itself will restore its normal function with its own regenerative ability (*2).
It is particularly recommended for patients who are concerned about the risk of conventional disc surgery (MED, PELD, etc.).

*1 Source: European Journal of Radiology 109 (2018) 101–107 , Efficiency of an ethyl alcohol gel in symptomatic disc hernation
*2 Source: International Journal of Spine Surgery Vol. 15 Appendix 1 from regenerative treatment of disc degeneration

*Medical institutions are required to have certifications like this one to perform the "Cellgel method".
*ILC International Lumbago Clinic is continuously working with doctors specializing in the Cellgel method, improving treatment techniques daily.

Features of Cellgel

  • Possibility to repair intervertebral discs where unable to using surgical or laser treatment
  • As the disc is repaired, the disc itself regains its original normal function through its own regenerative ability
  • The Cellgel method uses local anesthesia over general anesthesia used in conventional surgery, making it less burdensome on the body
  • Treatment is done with a thin needle, so the wound is minimal and recovery is rapid
  • Treatment is very short, allowing for outpatient day treatment
  • Safe, modern treatment proven in more than 54 countries around the world

Research and studies on Cellgel

Universities and hospitals around the world have published results on the treatment of the Cellgel method. The following are some highlights of the studies.
The figures below are cited directly from the figures in the studies; as described, this is a treatment that has been validated for its high rates of effectiveness.
The efficacy is the percentage of improvement in pain assessment scales such as VAS (Visual Analogue Scale) compared to before and after treatment.

No Country No. of patients Efficacy Rate Title of Research Paper (Original)
1 France 276 91% Percutaneous Treatment of Lumbar Interverteral Disk Hernias With Radiopaque Gelified Ethanol - A preliminary study
2 France 57 90% Percutaneous Treatment of Cervical Disk Hernias Using Gelified Ethanol
3 France 79 75% Percutaneous treatment of sciatica caused by a herniated disc: An exploratory study on the use of gaseous discography and Discogel1 in 79 patients
4 Italy 32 75% A Minimally Invasive Treatment for lumbar disc herniation: DiscoGel® Chemonucleolysis in Patients Unresponsive to Chemonucleolysis with Oxygen-Ozone
5 Greece 11 82% Intradiscal Combination of Pulsed Radiofrequency and Gelified Ethanol for the Treatment of Chronic Discogenic Low Back Pain
6 Italy 72 90% Lumbar Percutaneous Intradiscal Injection of Radiopaque Gelified Ethanol (“Discogel”) in Patients with Low Back and Radicular Pain
7 Italy 80 85% Percutaneous Injection of Radiopaque Gelified Ethanol for the treatment of lumbar and cervical Intervertebral disk herniations: Experience and Clinical Outcome in 80 Patients
8 France 42 86% Cohort study of lumbar percutaneous chemonucleolysis using ethanol gel in sciatica refractory to conservative treatment
9 Chile 9 100% Percutaneous treatment of cervical and lumbar disc herniation and discogenic pain with radiopaque gelified ethanol
10 Turkey 33 82% Long-term Clinical Effects of DiscoGel for cervical disc herniation
11 UAE 10 90% Cervical Discogenic Pain Treatment with Percutaneous Jellified Ethanol: Preliminary Experience
12 Slovenia 83 90% Efficacy and durability of radiopaque gelified ethanol in management of herniated discs
13 France 84 70% Predictive factors of Percutaneus treatment by DISCOGEL in sciatica or low back pain caused by a herniated disc.
14 Greece 25 76% Clinical outcome and safety of percutaneous Radiopaque Gelified Ethanol injection in patients with persisting lumbar disc herniation
15 Italy 94 91% Percutaneous intradiscal injection of radiopaque gelified ethanol: shortand long-term functional outcome and complication rate in a consecutive series of patients with lumbar disc herniation
16 Greece 36 93% Comparison of the Efficacy Between Intradiscal Gelified Ethanol (Discogel) Injection and Intradiscal Combination of Pulsed Radiofrequency and Gelified Ethanol (Discogel) Injection for Chronic Discogenic Low Back Pain Treatment. A Randomized Double-Blind Clinical Study
17 Poland 67 76% Efficacy of DiscoGel in Treatment of Degenerative Disc Disease: A Prospective 1-Year Observation of 67 Patients

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Treatment with Cellgel

After injecting local anesthesia, a 0.8 mm needle is inserted in the disc using a fluoroscopy device, injecting the treatment into the lumbar spine. Notably in prolapsed hernias, the more the gel permeates, the more effective the treatment is.

The treatment will not leave any visible scars on the body as only a thin needle is used. Moreover, as local anesthesia is used over general anesthesia, it puts less stress on the body, and patients can go home immediately after resting for an hour post-treatment.

Areas treated by the cellgel method
Under local anesthesia, a small needle is first inserted into the disc, then the implant gel is injected. The intervertebral disc is repaired by implantation of the Cellgel agent into the damaged nucleus. Furthermore, once repaired, the disc itself regains its original normal function through its own regenerative ability.

Conditions and Symptoms We Treat

  • Conditions / Spinal Diseases

    • Disc Herniation
    • Intervertebral Disc Degeneration
    • Spinal Stenosis
    • Spondylolisthesis
    • Spondylolysis / Spondylolytic Spondylolisthesis
    • Sciatica
    • Lumbar Osteoarthritis
    • Lumbar Instability
    • Degenerative Lumbar Scoliosis
    • Facet Joint Disease
    • Myofascial Low Back Pain
    • Sacroiliac Joint Disease
    • Lumbar Compression Fracture
    • Intermittent Claudication
  • Physical Symptoms

    • Collapsed disc
    • Disc appears black on the MRI
    • Disc has been depleted of its moisture
    • Deformed spine
    • Pain in lower back and/or buttocks
    • Pain in leg(s)
    • Numbness in lower back and/or buttocks, pain caused by numbness
    • Numbness in leg(s), pain caused by numbness
    • Pain and numbeness in only one leg
    • Unable to stand for a long time because of the pain
    • Unable to remain seated for a long time because of the pain
    • Unable to walk for long distances

*We will provide treatment only if we determine that our treatment is appropriate for these diseases and symptoms after a thorough medical examination.

For those with these concerns...

  • 1

    I've had chronic back pain for a long time, the pain and numbness have only gotten worse

  • 2

    Surgery for back pain (MED, spinal fusion, anaplasty, etc.) has been recommended before

  • 3

    I don't want to be hospitalized, I'm afraid of surgery

  • 4

    Past surgery did not improve my back pain (recurrence)

  • 5

    I have a busy schedule, I want a treatment that can be done in a day

  • 6

    I want a treatment that's less burdensome on the body

Elderly people (over 80 years old) are also eligible for this treatment

Merits of Cellgel

  • lower back pain

    Disc buffering (cushioning) Improved functionality

    As Cellgel remains as an implant in the disc, it also provides a cushioning function for the intervertebral disc.

  • short time

    Lowered stress on the body Outpatient treatment

    Treatment time is about 30 to 40 minutes, and patients are required to rest for about 60 minutes after treatment. One can return home after about 90 minutes from the start of the treatment.

  • treatment

    A new alternative to laser, ozone, and surgical treatment

    The Cellgel method is suitable even in cases where laser or surgery has proven to be ineffective.

Treatment time and side effects

Treatment Time
About 30-40 minutes

You will need to rest for about 60 minutes after treatment and you can go home after about 90 minutes. Light movement is possible from the next day onwards, but sports and strenuous activties must be put on hold for about a month.

  • Potential Drawbacks

    Symptoms may temporarily worsen for 1-2 weeks after treatment. This may be due to the decompression effect of the implant, which pulls in the surrounding tissues. In addition, if the disc is worn out and almost completely gone, treatment may not be possible. At the time of your visit, your doctor will have consultation to select the appropriate treatment method for your condition.

  • Potential Side Effects

    Transient pain may occur after the treatment. There are no reports of any neurological damage either in our own tests or studies. However, there is a very small possibility of an allergic reaction due to the local anesthetic.

Flow The Cellgel Treatment Process

  • Inquiry

    1. Inquiry

    Our clinic is by appointment only, so be sure to make an appointment before visiting us.

    Contact us on Whatsapp or by our contact form on this page.

  • MRI Image

    2. Remote MRI Diagnosis

    For Tokyo Clinic:
    An MRI scan will be performed at a clinic affiliated with our clinic before your appointment at our clinic. Please send the MRI CD-ROM data to us via email prior to your visit. Also, if you have MRI images taken at another hospital, please let us know when you contact us.

    For Osaka Clinic:
    The MRI scan will be performed at our clinic on the day of your appointment.

  • Choose Treatment Date Image

    3. Choose Treatment Date

    If the diagnosis confirms that you're a suitable candidate for our treatments, you may proceed to make an appointment with us. Kindly keep in mind the time it may take for you to secure a visa to enter Japan. A Japanese tourist visa is sufficient.

  • Travel Arrangements Image

    4. Travel Arrangements

    As we are an outpatient facility, you will be discharged on the same day as your treatment. Patients are asked to take care of their own visas, travel and accommodation arrangements.

  • Pre-treatment Examination Image

    5. Pre-Treatment Examination

    For Tokyo Clinic:
    Please have your health insurance card, various medical certificates, image data, etc. ready when you come to the reception desk. After the check-in,, we will take X-ray images. After the X-ray, the doctor will spend approximately 30 minutes thoroughly examining the patient, and will consider and recommend the most suitable treatment plan for each patient.

    At the Osaka Clinic:
    After the MRI/X-ray examination, the doctor will spend approximately 30 minutes thoroughly examining the patient, and will consider and propose the most appropriate treatment plan for each patient.

  • Treatment Image

    6. Treatment

    Patients who wish to be treated on the same day can choose to be treated in the afternoon after the examination in the morning. Treatment time varies from 15 to 45 minutes (per site) after local anesthesia is administered.

  • Discharge Image

    7. Discharge

    After the treatment, we provide a recovery room for you to rest for about an hour to 1.5 hours.
    You are free to return home after the doctor examines you.

  • Follow-up Image

    8. Follow-up

    We will contact you regularly for follow-ups after your treatment.
    If you have any questions, please feel free to contact us.

Price Cost of Treatment for the Cellgel Method

Number of
Discs Treated
1 disc 2 discs 3 discs 4 discs 5 discs
Treatment Cost 1,320,000 JPY 1,430,000 JPY 1,540,000 JPY 1,650,000 JPY 1,760,000 JPY

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* The cost of treatment is indicated including taxes.
*If treatment is performed at our clinic, all examination/diagnosis costs and test costs such as MRI are included in the above costs.
*This treatment method is not covered by Japanese health insurance, so you will have to pay for the entire treatment yourself.
*Payment by credit card (VISA, MasterCard, JCB, American Express, Diners, Discover) is also possible.
*If you would like rehabilitation (low back pain specialized rehabilitation), it is also possible to pay by bank transfer.
*If you live and work in Japan, you can receive a tax refund by filing your final medical expense return.

Other Treatment Methods

  • Florence Method

    A revolutionary new outpatient treatment for Spinal Stenosis! Used mainly in Europe and South America, it is now available at our clinic.

  • Hybrid Laser Method

    This is a minimally invasive treatment for disc herniation that combines the benefits of both laser therapy (PLDD) and ozone therapy (PODD).

  • PODD Method(Percutaneous Ozone Disc Decompression)

    Percutaneous Ozone Disc Decompression (PODD) has been performed mainly in Europe since the 1990s. It can be applied to facet joint disease, disc herniation, spinal canal stenosis, etc.

  • PLDD Method(Percutaneous Laser Disc Decompression)

    Percutaneous Laser Disc Decompression (PLDD) has been has been the major outpatient disc laser procedure in Japan since the 1980s. It is the primary treatment of choice for herniated discs.

Our Treatment Methods versus Conventional Surgical Procedures

Our clinic's treatments Traditional Surgery
Cellgel Hybrid Laser PODD PLDD Florence Micro Endoscopic
Discectomy (MED)
Spinal Stabilization
Disc Restoration × × × × × ×
Post-treatment Change
in Disc Volume
Same to increased Slight to small decrease Slight decrease Small decrease Same Decreased or disappeared Decreased or disappeared
Supressing of
× × × ×
Duration of
15–20 minutes 20–25 minutes 10–15 minutes 10–15 minutes 30 minutes 40 minutes – 1 hour 1–1.5 hours
Period of
About 1 week About 1 month
Treatable Symptoms &
Most lower back related conditions and symptoms Disc herniation Most lower back related conditions and symptoms Disc herniation Spinal canal stenosis, intervertebral disc hernia, facet joint disease, spondylolisthesis Disc herniation, spinal tumor etc. Spinal stenosis, spondylolisthesis, scoliosis, lumbar instability, intervertebral herniation, compression fracture

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FAQ Questions About Cellgel

What's the difference in the reccurence rate between Cellgel and conventional surgery?

Surgical procedures, which began in the 1960s, aimed to remove and sometimes fix deformed bones and herniated tissue. However, new bone damage caused by screws and the lack of fundamental treatment (repair of the intervertebral disc annulus fibrosus) resulted in the appearance of additional back pain and recurrence rates.

Therefore, in the 1980s, the need for fundamental treatment increased, and the intervertebral disc treatment (Cellgel) that we provide at our clinic began. Cellgel, in particular, have been proven to repair and regenerate the intervertebral disc, resulting in not only improvement of symptoms, but also an extremely low recurrence rate.

How is the number of sites or disc to be treated determined?
The doctor will spend about 30 minutes with the patient while looking at the MRI and X-ray images to determine the cause of the condition, determine the treatment area, and explain the corresponding treatment method to the patient. MRI images show the main factors that contribute to back pain (disc, nerve, ligament, and joint), such as changes in shape, pressure on the nerve, presence or absence of damage, and inflammation. The x-ray image mainly confirms the condition of the bones.
Why is the Cellgel method applicable to cases where previous surgical surgery showed no improvement?
During surgery for disc herniation, the prolapsed herniation is removed, but the damaged disc remains intact. As a result, fresh nucleus pulposus components leak from the damaged disc and inflammation persists. On the other hand, our treatment can treat the disc injury itself, thus suppressing inflammation by reducing the fresh leakage of nucleus pulposus components.
My back pain may temporarily worsen after treatment. How long will it last?
The reason for the lower back pain is that spinal ligaments that have been compressed are stretched; the lower back pain lasts for about two weeks and then subsides.
What level of exercise can I perform after treatment?
General recreational exercise and sports can be done without any problem. For professional athletes, the possibility of new disc damage is high and should be discussed in consultation with a doctor.
Please tell me about what I should be cautious about after treatment.
During the first few days after treatment, the patient should rest and avoid prolonged sitting, heavy lifting, twisting, bending, or strenuous exercise. Patients should be able to perform routine tasks one week after treatment and should be able to perform light exercise by the second week. Weight training is allowed after 3 months.
Is the treatment covered by the Japanese national health insurance?
No, it is not covered by the national insurance. If you have life insurance, you may be eligible. Please feel free to consult our staff regarding this matter.
How long must I wait to be able to walk after treatment?
It is an outpatient/day treatment, so you can walk about an hour after the surgery.
How many doctor visits do I need to make before treatment?
We require an MRI to be taken within three months for remote diagnosis, either with our affiliated clinic or from data sent by you. You can receive treatment on the same day after phyiscal diagnosis. You may also request only the diagnosis and come back only for the treatment at a later date.
Can I fly immediately after the treatment?
If there are no problems after the treatment, you may fly. If there is any pain after the treatment, flying may not be recommended depending on the doctor's evaluation.